The novel explores slavery's destructive effects on African-American families, the difficult lives of American mulattoes or mixed-race people, and the "degraded and immoral condition of the relation of master and slave in the United States of America." Featuring an enslaved mixed-race woman named Currer and her daughters Althesa and Clotel, fathered by Thomas Jefferson, it is considered a tragic mulatto story. The women's relatively comfortable lives end after Jefferson's death. They confront many hardships, with the women taking heroic action to preserve their families.