The goal of the NEO workshop series is to bring together experts from these and related fields to discuss, compare and merge their complementary perspectives in order to develop fast and reliable hybrid methods that maximize the strengths and minimize the weaknesses of the underlying paradigms. In doing so, NEO promotes the development of new techniques that are applicable to a broader class of problems. Moreover, NEO fosters the understanding and adequate treatment of real-world problems particularly in emerging fields that affect all of us, such as healthcare, smart cities, big data, among many others. The extended papers presented in the book contribute to achieving this goal.