This edition of DCAI brings together past experience, current work and promising future trends associated with distributed computing, artificial intelligence and their application to provide efficient solutions to real problems. This symposium is organized by the Bioinformatics, Intelligent System and Educational Technology Research Group (http://bisite.usal.es/) of the University of Salamanca. The present edition has been held in Salamanca, Spain, from 6 to 8 April 2011.