The 60 revised full papers presented together with 2 technical industrial papers were carefully reviewed and selected from 80 submissions. The papers are organized in the following topical sections: smart factory; digital twins; Internet of Things (IoT, IIoT); analytics in the order fulfillment process; ontologies for interoperability; tools to support early design phases; new product development; business models; circular economy; maturity implementation and adoption; model based systems engineering; artificial intelligence in CAx, MBE, and PLM; building information modelling; and industrial technical contributions.