Force Microscopy: Applications in Biology and Medicine
Bhanu P. Jena · J. K. Heinrich Hörber
Jun 2006 · John Wiley & Sons
Ebook
310
Pages
reportRatings and reviews aren’t verified Learn More
About this ebook
A complete examination of the uses of the atomic force microscope in biology and medicine
This cutting-edge text, written by a team of leading experts, is the first detailed examination of the latest, most powerful scanning probe microscope, the atomic force microscope (AFM). Using the AFM, in combination with conventional tools and techniques, readers gain a profound understanding of the cell, subcellular organelles, and biomolecular structure and function.
The text begins with three chapters describing the molecular machinery and mechanism of cell secretion and membrane fusion in cells, using approaches that combine AFM, electron microscopy, X-ray diffraction, photon correlation spectroscopy, molecular biology, biochemistry, and electrophysiology. The discovery of a new cellular structure the "porosome" or fusion pore--the cells secretory machinery, the molecular mechanism of membrane fusion in cells, and the expulsion of intravesicular contents during cell secretion are outlined in the first three chapters. The book also covers:
* Identification of the "porosome" in the growth hormone secreting cell of the pituitary gland
* Probing the structural and physical properties of microbial cell surfaces
* Scanning probe microscopic characterization of the higher plant cell wall and its components
* Case studies of nano drug delivery systems using engineered dendrimers
* AFM techniques for studying living cells
* Investigating the intermolecular forces of leukocyte adhesion molecules
* Protein-protein interactions
* Micromechanical properties of lipid bilayers and vesicles
The text concludes with four chapters that examine new and emerging approaches in the use of force microscopy in biology and medicine.
This text is ideal for advanced undergraduate and graduate students and researchers in cell and molecular biology, genetics, genomics, physiology, neuroscience, biophysics, and biochemistry. Not only does it provide the theory, but also practical considerations such as the selection of the right tools and approach.
This cutting-edge text, written by a team of leading experts, is the first detailed examination of the latest, most powerful scanning probe microscope, the atomic force microscope (AFM). Using the AFM, in combination with conventional tools and techniques, readers gain a profound understanding of the cell, subcellular organelles, and biomolecular structure and function.
The text begins with three chapters describing the molecular machinery and mechanism of cell secretion and membrane fusion in cells, using approaches that combine AFM, electron microscopy, X-ray diffraction, photon correlation spectroscopy, molecular biology, biochemistry, and electrophysiology. The discovery of a new cellular structure the "porosome" or fusion pore--the cells secretory machinery, the molecular mechanism of membrane fusion in cells, and the expulsion of intravesicular contents during cell secretion are outlined in the first three chapters. The book also covers:
* Identification of the "porosome" in the growth hormone secreting cell of the pituitary gland
* Probing the structural and physical properties of microbial cell surfaces
* Scanning probe microscopic characterization of the higher plant cell wall and its components
* Case studies of nano drug delivery systems using engineered dendrimers
* AFM techniques for studying living cells
* Investigating the intermolecular forces of leukocyte adhesion molecules
* Protein-protein interactions
* Micromechanical properties of lipid bilayers and vesicles
The text concludes with four chapters that examine new and emerging approaches in the use of force microscopy in biology and medicine.
This text is ideal for advanced undergraduate and graduate students and researchers in cell and molecular biology, genetics, genomics, physiology, neuroscience, biophysics, and biochemistry. Not only does it provide the theory, but also practical considerations such as the selection of the right tools and approach.
About the author
BHANU P. JENA, PHD, DSc, is the George E. Palade University Professor and Distinguished Professor of Physiology at Wayne State University School of Medicine, Detroit, Michigan. In addition, Dr. Jena is Director of the University's NanoBioScience Institute.
J. K. HEINRICH HÖRBER, PhD, is Professor in the Department of Physics at University of Bristol, Bristol, UK.
Rate this ebook
Tell us what you think.
Reading information
Smartphones and tablets
Install the Google Play Books app for Android and iPad/iPhone. It syncs automatically with your account and allows you to read online or offline wherever you are.
Laptops and computers
You can listen to audiobooks purchased on Google Play using your computer's web browser.
eReaders and other devices
To read on e-ink devices like Kobo eReaders, you'll need to download a file and transfer it to your device. Follow the detailed Help Center instructions to transfer the files to supported eReaders.
