Natural Hosts of SIV: Implication in AIDS

Aftab A. Ansari · Guido Silvestri

Jul 2014 · Newnes

Ebook

400

Pages

Eligible

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About this ebook

Natural Hosts of SIV: Implications in AIDS thoroughly reviews the possible mechanisms by which African nonhuman primate natural hosts of lentiviruses remain essentially disease-free while other hosts exhibit disease and death. The book ultimately indicates directions for further research and potential translations of this compelling phenomenon into novel approaches to treat and prevent HIV. When Asian non-human primate non-natural hosts are experimentally infected with viruses isolated from African species, disease and death normally results. Meanwhile, these African nonhuman primate natural hosts maintain similar levels of plasma and cellular viremia and exhibit compellingly different, essentially disease-free, states. This work attempts to answer the question of how the natural host remains disease resistant. - Summarizes the past 30 years of research in this field and describes the latest developments in AIDS research using nonhuman primate animal models - Provides insights into how this large body of scientific work can be translated into novel approaches to treat and prevent HIV - Highlights the areas that merit future pursuit, focusing on potential applications for the treatment and prevention of HIV infection

About the author

Aftab Ansari, Ph.D. Dr. Aftab A. Ansari, Professor, Department of Pathology and Laboratory Medicine, Room 2309 WMB, Emory University School of Medicine, 101 Woodruff Circle, Atlanta, GA 30322, USAPh.D., University of Arizona, Tucson, Arizona, 1970 M.S., University of California, Los Angeles, CA, 1967 M.S., University of Karachi, Karachi, Pakistan, 1963 B.S., University of Karachi, Karachi, Pakistan, 1961 1981-present Senior Consultant, Naval Medical Research and Development Command, Bethesda, Maryland1985-Present Professor, Department of Pathology and Laboratory Medicine, Emory University1999-present Scientific Advisor, U.S. Naval Medical Research Unit #2, Jakarta, Indonesia.2002-present Scientific Advisory Board, One World Health, San Francisco, CA.2001-2008 Scientific Advisory Board, Lipid Sciences, Inc. Pleasanton, CA.2005-present Scientific External Advisory Board member, CAHDR, Meharry Medical College, Nashville, TN2008-present Scientific Advisory Board, SMART Technologies, Inc., Rehovot, Israel2007-present Member, FDA Expert Panel, FDA Center for Devices and Radiological Health (CDRH), SGE, Deptt. Of Health & Human Services, Immunology Devices Panel

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